Lycopene is a member of a carotenoid family and is naturally abundant in tomatoes. The consumption of lycopene is already needed for human because it acts as an antioxidant, meanwhile, our body cannot produce that naturally. Previous studies have shown that there is an inverse relationship between dietary lycopene intake and the risk of PCa. However, the studied mechanism underlying how the lycopene affects or inhibit the control of cancer growth, in this case, is DNA-methyltransferase that can regulate the cancer genes, is still limited, and even absent. Motivated by that, a series of the method including preparation docking, molecular docking, and identifying the biological activity were done to study the mechanism of lycopene in reducing the DNMT. The result of lycopene-DNMT binding was compared with other known ligands that already known to bind the DNMT in its active site, which is SFG and SAH. The docking results showed that the binding affinity of lycopene and DNMT is lower than other ligands. The biological activity analysis also showed that lycopene is proven to have antioxidant activity, however, it still needs further study or experimental work to prove its ability for apoptosis agonist or as anti-proliferative disease because it is only computationally proven.
American Cancer Society (2012) Cancer Facts and Figures. [accessed 13.07. 2012].
Bennett LL, Rojas S, & Seefeldt T (2012) Role of Antioxi-dants in the Prevention of Cancer. Journal of Experimental and Clinical Medicine 4 (4): 215-222. doi.org/10.1016/j.jecm.2012.06.001.
Robertson KD (2005) DNA methylation and human dis-ease. Nat Rev Genet 6(8):597–610.
Aldawsari FS, Aguayo-Ortiz R, Kapilashrami K, Yoo J, Luo M, Medina-Franco JL & Velázquez-Martínez CA (2015) Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31 (5), 1–9. doi.org/10.3109/14756366.2015.1058256.
Du X, Li Y, Xia YL, Ai SM., Liang J, Sang P, Liu SQ (2016) Insights into Protein-Ligand Interactions: Mecha-nisms, Models, and Methods. International Journal of Mo-lecular Sciences, 17(2): 1-34.doi.org/10.3390/ijms17020144.
Alberty RA (1969) Standard Gibbs Free Energy, Enthalpy, and Entropy Changes as a F-unction of pH and pMg for Several Reactions Involving Adenosine Phosphates. The Journal Of Biological Chemistry 244(12): 329–3302.
Agonist - Biology-Online Dictionary (2008) Retrieved May 7, 2017, from http://www.biology-online.org/dictionary/Agonist.
Sporn MB & Harris ED (1981) Proliferative diseases. The American Journal of Medicine, 70(6), 1231–5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/6263092