Potential of Lime Juice with Dregs on Lipid Profiles in Mice Using Depo Medroxy Progesterone Acetate (DMPA)

Abstract

Depo Medroxy Progesterone Acetate (DMPA) is an injectable method for contraception, containing progesteron, with high pregnancy protection (99,9%). However, the use of DMPA may result in imbalance of estrogen, in turn, can decrease High Density Lipoprotein (HDL) and increase Low Density Lipoprotein (LDL). A study on the use of DMPA showed a decrease in HDL cholesterol while an increase in LDL cholesterol and total cholesterol. Flavonoids from citrus fruits, in the form of hesperidin, can increase HDL cholesterol levels in hypercholesterolemic human subjects. Another study also stated that giving lime juice increased HDL cholesterol levels. The purpose of this study was to determine the effectiveness of lime juice with pulp in increasing HDL cholesterol levels in mice using Depo Medroxy Progesterone Acetate (DMPA). Method: The method in this study is an experimental study with a pretest-posttest control group design. Results: Potential of Lime Juice with Dregs on Livid Profile in Mice using DMPA. The data were analyzed by using the Paired t-test parametric test to compare between treatment groups. There is an effect of giving lime juice without pulp on day 35 and giving lime juice with pulp on day 14 and day 35 on HDL levels of mice given DMPA injection. There was no effect of giving lime juice without pulp on day 14 and day 35 as well as giving lime juice with pulp on day 14 and day 35 on LDL levels of mice given DMPA injection. There was an effect of giving lime juice without pulp on day 35 and giving lime juice with pulp on day 14 and day 35 on the triglyceride levels of mice given DMPA injection. There is an effect of giving lime juice with dregs on day 14 and day 35 on total cholesterol levels in mice given DMPA injection. Conclusions: Giving lime juice with pulp can be recommended as a product that can be consumed to lower cholesterol levels.