FUNDAMENTALS OF PROTEIN-PROTEIN INTERACTIONS AND THEIR METHODS OF CHARACTERIZATION

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Published Dec 31, 2021
https://doi.org/10.11594/bbrj.04.02.04
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Vol. 4 No. 2 (2021): Volume 4 Issue 2

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Kholis Audah
Swiss German University

Abstract

Protein-protein interactions are ubiquitous biological phenomena in all types of organism and play vital roles in various metabolic processes. Therefore, it is very important to understand how protein-protein interactions take place and govern different mechanisms at cellular and molecular levels. Thus, determination of protein-protein interactions is the key in elucidating such mechanisms. In order to provide adequate knowledge and guidance in selecting appropriate methods to determine protein-protein interactions, this article will review basic principles, definitions, terminologies, parameters and classification of protein-protein interactions, obtained either from in silico or laboratory experimental works. Some examples of commonly used biochemical and biophysical methods for characterization of protein-protein interactions were also discussed.

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite
Audah, K. (2021) “FUNDAMENTALS OF PROTEIN-PROTEIN INTERACTIONS AND THEIR METHODS OF CHARACTERIZATION”, Bioinformatics and Biomedical Research Journal, 4(2), pp. 70–82. doi: 10.11594/bbrj.04.02.04.

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